Peripheral and central chemoreceptor reflex regulation of sympathetic activity in heart failure patients with and without sleep apnea

伴或不伴睡眠呼吸暂停的心力衰竭患者交感神经活动的外周和中枢化学感受器反射调节

• 批准号: 381722
• 负责人: Floras John S
• 金额: $ 26.19万
• 依托单位: University Health Network (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=381722&lang=en
• 关键词: Autonomic Reflexes; Central Chemoreceptor Reflexes; Heart Failure; Human Research; Peripheral Chemoreceptor Reflexes; Sleep Apnea

When the heart fails to pump normally, the brain releases into the bloodstream more of a molecule called noradrenaline (NA). NA increases heart rate, retains salt and water and constricts blood vessels. At first, more NA improves heart function but over t

当心脏无法正常泵血时，大脑会向血液中释放更多一种称为去甲肾上腺素 (NA) 的分子。 NA 会增加心率、保留盐和水并收缩血管。起初，更多的 NA 可以改善心脏功能，但超过 t