Canada Research Chair in Stereoselective Synthesis of Bioactive Molecules

加拿大生物活性分子立体选择性合成研究主席

• 批准号: 1000227346-2011
• 负责人: Charette, André
• 金额: $ 14.57万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642948
• 关键词: Canada; Research; Chair; Stereoselective; Synthesis

Most of the important molecules found in Nature (enzymes, proteins, RNA, DNA, etc.) are chiral and cannot be superimposed upon their mirror image. Yet, they are the most challenging ones to selectively synthesize due to their inherent similarity between various chemical structures and, while one form may be beneficial to health, the other may be harmful. Our research is directed towards the stereoselective synthesis of new and potentially bioactive organic compounds. We develop novel catalytic methods and tools to speed up drug synthesis and generate new beneficial chiral molecules, which are critical intermediates leading to many of the new products in medicine, pharmaceuticals, agrochemicals, biology, food science as well as in materials science.

自然界中发现的大多数重要分子（酶、蛋白质、RNA、DNA 等）都是手性的，不能叠加在它们的镜像上。然而，由于它们各种化学结构之间固有的相似性，它们是选择性合成最具挑战性的，虽然一种形式可能对健康有益，但另一种形式可能有害。我们的研究针对新型且具有潜在生物活性的有机化合物的立体选择性合成。我们开发新颖的催化方法和工具来加速药物合成并生成新的有益手性分子，这些分子是产生医学、制药、农用化学品、生物学、食品科学以及材料科学领域许多新产品的关键中间体。