Probing the Dye Chemistry of Genipin-Based Temporary Tattoos Using a Self-Assembled Monolayer Skin Mimic

使用自组装单层皮肤模拟物探索基于京尼平的临时纹身的染料化学

基本信息

批准号：
521906-2017
负责人：
Carmichael, Tricia
金额：
$ 1.82万
依托单位：
University of Windsor
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2017
资助国家：
加拿大
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639981
关键词：
Probing Dye Chemistry Genipin Based

项目摘要

Inkbox is a company in Toronto that has commercialized the world's first two-week tattoo. This technology hasornamental applications, as well as exciting potential in medical applications. The key to this technology in anactive ingredient derived from a fruit extract called Genipin, which has previously been explored as a non-toxiccrosslinking reagent for tissue engineering and materials science. When Genipin is applied to the skin, ittransforms into a vibrant blue colour. Although the chemistry behind this transformation is not wellunderstood, it is believed to bind to the skin by reacting with amino acids, and then undergo furtheroligomerization reactions to form the vibrant blue colour of the tattoo. In this proposal, we will use a synthetic"skin mimic" to acquire a better understanding of this reaction process under controlled conditions. Our skinmimic will comprise a layer of molecules adhered to a solid surface that is amenable to advanced spectroscopicanalysis. We will bind Genipin to the skin mimic and study its reactivity, using spectroscopic data to establishthe binding as well as the subsequent reactions that cause the blue colouration of Inkbox tattoos. These studieswill help Inkbox optimize its formulation to enhance skin penetration and increase tattoo longevity, and alsoprovide insight into how intermolecular interactions may be able to alter the colouration of the product.

Inkbox是多伦多的一家公司，已将世界上第一个为期两周的纹身商业化。这项技术的Hasormental应用程序以及医疗应用中的令人兴奋的潜力。这项技术的关键是从一个称为Genipin的水果提取物中得出的，该提取物以前已被探讨为组织工程和材料科学的非刺激性互动试剂。当Genipin应用于皮肤上时，ITTRANSFORM将其变成充满活力的蓝色。尽管这种转化背后的化学尚未得到充分闻名，但据信它通过与氨基酸反应，然后经历远远聚集反应来与皮肤结合，形成纹身的充满活力的蓝色。在此提案中，我们将使用合成的“皮肤模仿”来更好地理解该反应过程在受控条件下。我们的皮肤敏捷将包含一层粘附在固体表面上的分子，该分子可适应晚期光谱分析。我们将使用光谱数据结合金蛋白与皮肤模仿并研究其反应性。这些研究将帮助Inkbox优化其配方，从而增强皮肤穿透并增加纹身的寿命，并对分子间相互作用如何能够改变产品的颜色的洞察力。