Investigating peptide signaling controlling plant development in Arabidopsis

研究控制拟南芥植物发育的肽信号传导

基本信息

批准号：
RGPIN-2015-06626
负责人：
Lee, JinSuk
金额：
$ 3.28万
依托单位：
Concordia University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2017
资助国家：
加拿大
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630360
关键词：
Investigating peptide signaling controlling plant

项目摘要

Cell-cell communication is integral to the evolution of multicellularity. In plants, intercellular signaling mediated by peptide ligands has emerged as a key component of growth and development. Plants possess many genes encoding small, secreted peptides and receptor kinases, which occur in gene families and often have redundant functions. Although exciting progress has been made in understanding peptide signaling in plants, how different peptide signals are correctly interpreted to control diverse developmental processes is poorly understood. This proposal aims to address a major unresolved question in peptide signaling and plant development: how peptide ligands elicit unique biological responses using the same sets of receptors. We focus on two classes of the plant peptide family known to play an overlapping yet unique role in various developmental processes in Arabidopsis. We will fill the major gap between receptors and downstream signaling pathways in inflorescence and stomatal development, and study the relationship between peptide binding and receptor differential activation to decipher the mechanisms of signaling specificity. We will further uncover the function of a specific peptide family in stomatal patterning. This research will bring significant insights into our understanding of molecular complexity, specificity, and the dynamics of peptide signaling that enforces proper development in plants. A deep understanding of the mechanisms controlling plant development will allow us to develop strategies to improve water-use efficiency and biomass production of agriculturally important plants.

细胞 - 细胞通信是多细胞演变不可或缺的。在植物中，由肽配体介导的细胞间信号传导已成为生长和发育的关键组成部分。植物具有编码小的，分泌的肽和受体激酶的许多基因，这些基因发生在基因家族中，通常具有冗余功能。尽管在理解植物中的肽信号传导方面已经取得了令人兴奋的进步，但如何正确解释了不同的肽信号以控制多种发育过程。该提案旨在解决肽信号传导和植物发育中的一个主要未解决的问题：肽配体如何使用相同的受体引起独特的生物学反应。我们专注于已知的两类植物肽家族，它们在拟南芥的各种发育过程中起着重叠而独特的作用。我们将在花序和气孔发育中填补受体和下游信号通路之间的主要空白，并研究肽结合与受体差异激活之间的关系以破译信号特异性的机制。我们将进一步发现特定肽家族在气孔图案中的功能。这项研究将为我们对分子复杂性，特异性和肽信号的动力学的理解带来重大见解，从而实施植物中适当发育的肽信号传导。对控制植物开发的机制有深刻的了解将使我们能够制定策略，以提高农业重要植物的水利用效率和生物量生产。