Discovery of catalytic tools for isoprenoid production

发现类异戊二烯生产的催化工具

• 批准号: RGPIN-2017-04874
• 负责人: Ro, DaeKyun
• 金额: $ 2.84万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630307
• 关键词: Discovery; catalytic; tools; isoprenoid; production

The isoprenoids are a large and structurally diverse class of natural products with more than 55,000 known compounds. Many isoprenoids have been used as flavors, pharmaceuticals, and industrial polymers. All isoprenoids are currently supplied either by purification from plants or by chemical synthesis involving petrochemicals. However, the yield from natural sources is often inadequate to meet industrial demands, and chemical synthesis is not desirable due to environmental perturbation. To overcome these, the enzymatic production of isoprenoids using biological systems has become an attractive alternative to the traditional purification and chemical synthesis; however, our current knowledge of isoprenoid metabolism remains insufficient to realize the biological supply of isoprenoids.

类异on-是一种大型且结构上多样的天然产物，具有超过55,000种已知化合物。许多类异on-已用作口味，药物和工业聚合物。目前，所有类异丙生素都是通过植物纯化或涉及石化物质的化学合成来提供的。但是，自然来源的产量通常不足以满足工业需求，并且由于环境扰动而无法获得化学合成。为了克服这些，使用生物系统的类异丙定酶的酶促产生已成为传统纯化和化学合成的有吸引力的替代品。但是，我们目前对异丙代谢的知识仍然不足以实现类吸收的生物供应。