Discovery of catalytic tools for isoprenoid production

发现类异戊二烯生产的催化工具

• 批准号: RGPIN-2017-04874
• 负责人: Ro, DaeKyun
• 金额: $ 2.84万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630307
• 关键词: Discovery; catalytic; tools; isoprenoid; production

The isoprenoids are a large and structurally diverse class of natural products with more than 55,000 known compounds. Many isoprenoids have been used as flavors, pharmaceuticals, and industrial polymers. All isoprenoids are currently supplied either by purification from plants or by chemical synthesis involving petrochemicals. However, the yield from natural sources is often inadequate to meet industrial demands, and chemical synthesis is not desirable due to environmental perturbation. To overcome these, the enzymatic production of isoprenoids using biological systems has become an attractive alternative to the traditional purification and chemical synthesis; however, our current knowledge of isoprenoid metabolism remains insufficient to realize the biological supply of isoprenoids.

类异戊二烯是一大类结构多样的天然产物，已知化合物超过 55,000 种。许多类异戊二烯已被用作香料、药物和工业聚合物。目前，所有类异戊二烯都是通过植物纯化或涉及石化产品的化学合成提供的。然而，天然来源的产量通常不足以满足工业需求，并且由于环境扰动，化学合成也不可取。为了克服这些问题，使用生物系统酶法生产类异戊二烯已成为传统纯化和化学合成的有吸引力的替代方案；然而，我们目前对类异戊二烯代谢的了解仍然不足以实现类异戊二烯的生物供应。