Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function

对核仁结构和功能调节的生物化学、蛋白质组学和微观见解

• 批准号: RGPIN-2015-06674
• 负责人: TrinkleMulcahy, Laura
• 金额: $ 2.48万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629546
• 关键词: Biochemical; proteomic; microscopic; insights; into

The mammalian nucleolus is a non membrane-bound nuclear organelle that forms around tandem repeats of ribosomal DNA and is best known for its essential role in the coordination of ribosome biogenesis, which supplies the cell with the ribosome complexes required for protein synthesis. This structure is dynamic, disassembling and reassembling throughout each cell cycle in mammalian cells and reorganizing its internal structure in response to various cellular stresses.

哺乳动物核仁是一种非膜结合的核细胞器，围绕核糖体DNA的串联重复序列形成，以其在核糖体生物发生协调中的重要作用而闻名，该作用为细胞提供了蛋白质合成所需的核糖体复合物。在哺乳动物细胞中，整个细胞周期中，这种结构是动态的，分解和重新组装的，并对各种细胞应激进行了重组。