Impact of BHV-1 tegument proteins on the innate response to infection and virion morphogenesis.

BHV-1 外皮蛋白对感染和病毒颗粒形态发生的先天反应的影响。

• 批准号: RGPIN-2016-06230
• 负责人: vanDrunenLittelvandenHurk, Sylvia
• 金额: $ 3.21万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629470
• 关键词: Impact; BHV; tegument; proteins; innate

Bovine herpesvirus-1 (BoHV-1) has a severe impact on growth, milk production, and international livestock trade, thus being responsible for major economic damage to the cattle industry worldwide. In North America BoHV-1 is part of the bovine respiratory disease complex, which costs the cattle industry >1 billion dollars each year. In addition, BoHV-1 is an emerging virus in buffalo. Herpesviruses are composed of four concentric compartments, the nucleoprotein core, capsid, tegument and envelope. Tegument proteins are the first to interact with the intracellular environment and at a later stage associate to create the tegument of new virions. Some herpesvirus tegument proteins have important functions, for instance in regulation of transcription and in virus morphogenesis. The mechanism and site of BoHV-1 tegument formation, and the functions of its protein components are largely unknown.

牛疱疹病毒-1（BOHV-1）对生长，牛奶产量和国际牲畜贸易有严重影响，因此对全球牛业的重大经济损害负责。在北美，Bohv-1是牛呼吸道疾病综合体的一部分，该疾病综合体的损失量高10亿美元。此外，BOHV-1是布法罗的一种新兴病毒。疱疹病毒由四个同心隔室组成，即核蛋白核心，衣壳，tegument和包膜。 Tegument蛋白是第一个与细胞内环境相互作用的蛋白质，并在以后的阶段相互作用，以创建新病毒体的tegument。一些疱疹病毒tegument蛋白具有重要功能，例如在调节转录和病毒形态发生方面。 BoHV-1 Tegument形成的机理和部位及其蛋白质成分的功能在很大程度上未知。