SRF-independent roles of Myocardin in differentiation of vascular smooth muscle cells

心肌素在血管平滑肌细胞分化中的 SRF 独立作用

• 批准号: RGPIN-2017-04889
• 负责人: Zheng, XiLong
• 金额: $ 1.89万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629311
• 关键词: SRF; independent; roles; Myocardin; differentiation

It is critical to understand the molecular mechanisms underlying the regulation of vascular functions. The medial layers of blood vessels are composed of smooth muscle cells (SMCs), which perform the contractile functions of blood vessels, arteries in particular. The differentiation of vascular SMCs and their associated contractile functions are under the control of myocardin, a master transcriptional co-factor that activates the transcription of genes that encode smooth muscle-specific contractile proteins. During aging and the onset of age-related vascular pathologies, vascular SMCs undergo phenotypic conversion, which is associated with loss of the differentiated/contractile phenotype, and concomitant acquisition of a synthetic phenotype, including enhanced proliferation,

了解血管功能调节的分子机制至关重要。血管的内层由平滑肌细胞（SMC）组成，其执行血管，特别是动脉的收缩功能。血管 SMC 的分化及其相关的收缩功能受到心肌素的控制，心肌素是一种主要的转录辅助因子，可激活编码平滑肌特异性收缩蛋白的基因的转录。在衰老和与年龄相关的血管病变发生期间，血管 SMC 经历表型转换，这与分化/收缩表型的丧失相关，并伴随获得合成表型，包括增殖增强、