Stimulation of immune responses to aid in prevention of bovine respiratory disease

刺激免疫反应以帮助预防牛呼吸道疾病

• 批准号: 476331-2014
• 负责人: Caswell, Jeffrey
• 金额: $ 4.58万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619160
• 关键词: Stimulation; immune; responses; aid; prevention

Bovine respiratory disease is a common disease of cattle with much economic impact on the Canadian beef industry. The disease most commonly occurs when calves are weaned, transported long distances, and mingled with calves from other sources. Thus, stress and viral infection are major risk factors that lead to development of bacterial pneumonia in cattle. The present research seeks to understand the mechanisms by which stress (modeled by glucocorticoids) interferes with immune responses in the respiratory tract of cattle, and how to develop interventions to prevent this suppression of the respiratory immune system. Such an intervention would be of value in preventing respiratory disease in beef cattle in feedlots, and may reduce the need for preventative use of antibiotics in beef production.

牛呼吸道疾病是牛的常见疾病，对加拿大牛肉业有很大的经济影响。这种疾病最常发生在犊牛断奶、长途运输以及与其他来源的犊牛混合时。因此，应激和病毒感染是导致牛发生细菌性肺炎的主要危险因素。本研究旨在了解压力（以糖皮质激素为模型）干扰牛呼吸道免疫反应的机制，以及如何制定干预措施来防止呼吸道免疫系统受到抑制。这种干预对于预防饲养场肉牛的呼吸道疾病很有价值，并且可以减少牛肉生产中预防性使用抗生素的需求。