The effect of in ovo delivery of nutrients and feed additives on the development of the immune system

营养物质和饲料添加剂的卵内输送对免疫系统发育的影响

• 批准号: 505352-2016
• 负责人: Sharif, Shayan
• 金额: $ 2.19万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619157
• 关键词: effect; ovo; delivery; nutrients; feed

The research proposed here focuses on in ovo supplementation of chick embryos with vitamins and probiotic bacteria. Newly hatched chicks are subject to various forms of stress that make them more susceptible to pathogens. Chicks can be made healthier by early interventions, such as by pre-hatch administration of nutrients and/or beneficial bacteria. More specifically, we intend to take a systematic approach and examine how these interventions can enhance the chicken's immune system health. Research into in ovo nutrition has demonstrated improvements in hatch weight and growth, digestive capacity, reduced post-hatch mortality and morbidity, and improved immune response. Probiotics have been shown to improve growth performance and feed efficiency, antibody response, and to limit food-borne pathogens. Given the potential of nutrients and probiotics to stimulate intestinal and immune system development, in ovo treatment could provide a natural barrier to pathogen colonization and allow accelerated intestinal and immune system development resulting in increased growth and health of birds. Given the routine in ovo use of various vaccines, anything else administered in ovo, in addition to having a positive effect on health and performance, must not interfere with vaccine efficacy.

这里提出的研究重点是在鸡胚卵内补充维生素和益生菌。刚孵出的小鸡会受到各种形式的压力，这使它们更容易受到病原体的影响。通过早期干预，例如通过孵化前施用营养物质和/或有益细菌，可以使雏鸡变得更健康。更具体地说，我们打算采取系统方法，研究这些干预措施如何增强鸡的免疫系统健康。卵营养研究表明，孵化重量和生长、消化能力得到改善，孵化后死亡率和发病率降低，免疫反应得到改善。益生菌已被证明可以改善生长性能和饲料效率、抗体反应并限制食源性病原体。鉴于营养素和益生菌具有刺激肠道和免疫系统发育的潜力，卵内治疗可以为病原体定植提供天然屏障，并加速肠道和免疫系统发育，从而促进鸟类的生长和健康。鉴于各种疫苗的卵内使用是常规的，卵内施用的任何其他药物除了对健康和性能产生积极影响外，不得干扰疫苗功效。