Applying unique zebrafish models to elucidate and functionally validate the molecular genetic causes of adolescent idiopathic scoliosis

应用独特的斑马鱼模型阐明和功能验证青少年特发性脊柱侧凸的分子遗传原因

• 批准号: 342981
• 负责人: Ciruna Brian G
• 金额: $ 66.28万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=342981&lang=en
• 关键词: Cerebrospinal Fluid Flow; Developmental Genetics; Idiopathic Scoliosis; Motile Cilia Function; Whole Genome Sequencing; Wnt Signalling; Zebrafish Models Of Human Disease; Cerebrospinal Fluid Flow; Developmental Genetics; Idiopathic Scoliosis; Motile Cilia Function; Whole Genome Sequencing; Wnt Signalling; Zebrafish Models Of Human Disease

Idiopathic scoliosis (IS) is a complex genetic disorder characterized by three-dimensional spinal curvatures that typically arise during adolescence in otherwise healthy individuals. IS afflicts 3% of children worldwide and, in severe cases, can produce c

特发性脊柱侧弯（IS）是一种复杂的遗传疾病，其特征是三维脊髓曲率，通常在青春期中在其他健康的个体中出现。是全球3％的儿童折磨吗？在严重的情况下，会产生C