Investigating the link between cilia function and adolescent idiopathic scoliosis

研究纤毛功能与青少年特发性脊柱侧弯之间的联系

• 批准号: 320408
• 负责人: Ciruna Brian G
• 金额: $ 56.14万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=320408&lang=en
• 关键词: Cell Biology; Cilia And Basal Body Function; Live Confocal Microscopy; Planar Cell Polarity; Polarized Cell Movement; Scoliosis; Wnt Signal Transduction; Zebrafish Developmental Genetics; Cell Biology; Cilia And Basal Body Function; Live Confocal Microscopy; Planar Cell Polarity; Polarized Cell Movement; Scoliosis; Wnt Signal Transduction; Zebrafish Developmental Genetics

Scoliosis is a complex genetic disorder characterized by rotational deformity of the spine. Congenital scoliosis is apparent at birth, whereas Idiopathic Scoliosis (IS) develops later during adolescence and afflicts 3% of children worldwide. If left untr

脊柱侧弯是一种复杂的遗传疾病，其特征是脊柱旋转畸形。先天性脊柱侧弯显然是出生时明显的，而特发性脊柱侧弯（IS）在青春期后期出现，全球3％的儿童折磨。 如果离开