Prenatal stress affects on mammalian neocortex development and long-term neurobehavioural responses to stress

产前应激影响哺乳动物新皮质发育和对应激的长期神经行为反应

• 批准号: 436204-2013
• 负责人: Weaver, Ian
• 金额: $ 2.33万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596888
• 关键词: Prenatal; stress; affects; mammalian; neocortex

This research program examines how early environmental experience affects mammalian brain development and adult behaviour. Glucocorticoids (GCs)-a type of steroid hormone that plays an important role during fetal development-are administered as standard treatment for a number of conditions in obstetrics and perinatal medicine, however the effects of increased GC exposure on early life development of the brain remain unknown. Studies have demonstrated that GCs have a profound influence on offspring, affecting social, emotional and cognitive development, which is endured through life.

该研究计划研究早期环境经历如何影响哺乳动物的大脑发育和成年行为。糖皮质激素 (GC) 是一种在胎儿发育过程中发挥重要作用的类固醇激素，在产科和围产期医学中被作为多种疾病的标准治疗方法，但 GC 暴露增加对大脑早期发育的影响仍然存在未知。研究表明，GC 对后代具有深远的影响，影响社交、情感和认知发展，并伴随一生。