The maintenance of [Ca2+]c oscillations in pituitary gonadotrophs and its impact on secretion

垂体促性腺激素中[Ca2]c振荡的维持及其对分泌的影响

• 批准号: 327330-2012
• 负责人: Tse, Amy
• 金额: $ 2.04万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595226
• 关键词: maintenance; Ca2+; oscillations; pituitary; gonadotrophs

In cells that secrete hormone, a rise in the level of calcium is the signal for the cell to secrete hormone. In order to maintain secretion, calcium has to enter the cells by some pathways. Without these calcium entering pathways, cells cannot continue to secrete hormone. We investigate the nature and the components of the calcium entering pathway that is needed to maintain hormone secretion. The results from our study will help to understand how cells control hormone secretion. This knowledge will be useful in developing drugs to control hormone secretion in diseases related to excessive or deficiency in hormone secretion.

在分泌激素的细胞中，钙水平的升高是细胞分泌激素的信号。为了维持分泌，钙必须通过某些途径进入细胞。如果没有这些钙进入途径，细胞就无法继续分泌激素。我们研究维持激素分泌所需的钙进入途径的性质和成分。我们的研究结果将有助于了解细胞如何控制激素分泌。这些知识将有助于开发药物来控制与激素分泌过多或不足相关的疾病的激素分泌。