Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media

多重散射非均匀双折射介质中的偏振穆勒矩阵成像

• 批准号: 194509-2013
• 负责人: Vitkin, Alex
• 金额: $ 2.99万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593709
• 关键词: Polarimetric; Mueller; matrix; imaging; multiply

Light provides us with much useful information about our surroundings. In addition to its wavelength (colour) and intensity, another useful property of an optical beam is its polarization state, or the orientation of the electric field vector perpendicular to the propagation direction. When light interacts with an object, its polarization state will be changed. Hence the properties of the object can be obtained by measuring this change. Here, we propose to extend our research into polarized light interactions with turbid materials. The long-term goal of the research is to perform polarized light assessment of biological tissues. The numerous deflections experienced by the light in such materials will significantly scramble its polarization. However, we and others have shown that a surprising amount of useful polarization information can be still retained upon such multiple scattering. The proposed methodology will thus optimize measurements and analysis of polarization effects in turbid media. These methods can then be used to characterize turbid systems such as planetary atmospheres, biological tissues, or amorphous semiconductors. It is also proposed to investigate the effects of the medium "birefringence". This refers to the structural asymmetry / microarchitectural organization of some materials, which causes them to interact with polarized light in distinctive ways. Polarization measurements have long been used in TRANSPARENT media or thin materials (thin films) to probe the details of its structure. The proposed work is novel in its intent to quantify these structural asymmetries in optically thick TURBID media. Significance in the biomedical arena stems from the asymmetric nature of many biological tissues, and microstructural rearrangements as a result of disease progression or treatments. Our polarized light approach can then report on tissue functional status and tissue viability in urology (bladder wall anisotropy, structure-function relationship in obstructed bladder disease), cardiology (heart muscle remodelling following infarct and stem-cell regenerative therapies) and oncology (breast cancer metastatic spread along anisotropic routes in the tumour extracellular matrix).

Light为我们提供了有关周围环境的许多有用的信息。除了其波长（颜色）和强度外，光束的另一个有用的特性是其极化状态，或垂直于传播方向的电场矢量的方向。当光与对象相互作用时，其极化状态将被更改。因此，可以通过测量此更改来获得对象的属性。在这里，我们建议将研究扩展到与浑浊材料的两极分化光相互作用中。该研究的长期目标是对生物组织进行两极分化的光评估。这些材料中光经历的众多偏转将大大扰乱其极化。但是，我们和其他人表明，在如此多的散射中仍然可以保留大量有用的极化信息。因此，提出的方法将优化浑浊介质中极化效应的测量和分析。然后，这些方法可用于表征浊度系统，例如行星大气，生物组织或无定形半导体。还建议研究“双折射”培养基的影响。这是指某些材料的结构不对称 /微体系结构组织，这使它们以独特的方式与极化光相互作用。极化测量长期以来一直在透明的培养基或薄材料（薄膜）中，以探测其结构的细节。拟议的工作是新颖的，目的是量化光学较厚的浑浊介质中的这些结构不对称。生物医学领域的重要性源于许多生物组织的不对称性质，以及由于疾病进展或治疗而导致的微观结构重排。然后，我们的极化光方法可以报告泌尿科中的组织功能状态和组织活力（膀胱壁各向异性，膀胱疾病阻塞的结构功能关系），心脏病学（梗塞后心肌重塑和干细胞再生疗法后心肌重塑）和肿瘤学（乳腺癌转移沿Tumore intracriact in themortrar in themorrix in themor care）。