The Total Synthesis of Bioactive Molecules and the Development of the Methodological Underpinning

生物活性分子的全合成及其方法基础的发展

• 批准号: 155431-2012
• 负责人: Kerr, Michael
• 金额: $ 7.36万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593492
• 关键词: Total; Synthesis; Bioactive; Molecules; Development

This proposal describes the development of new and useful chemical transformations and the application of those transformations to the challenge of preparing, by chemical synthesis, target molecules of biological or medicinal significance. Our research group has the long term goals of: 1) Uncovering previously unknown reactivity of existing functional groups with the aim of developing new, useful synthetic methods, 2) developing the chemistry of donor-acceptor cyclopropanes, 3) exploring new Conia-ene chemistry, 4) developing new ways to prepare and functionalize heterocyclic motifs, and 5) applying the synthetic methods above to the expedient synthesis of natural and unnatural target molecules possessing important biological activity.

该提案描述了新的和有用的化学转化的发展以及这些转化在通过化学合成制备具有生物或医学意义的目标分子的挑战中的应用。我们的研究小组的长期目标是：1) 揭示现有官能团以前未知的反应性，旨在开发新的、有用的合成方法，2) 开发供体-受体环丙烷的化学，3) 探索新的 Conia-ene 化学，4）开发新的方法来制备和功能化杂环基序，以及5）应用上述合成方法来方便地合成具有重要生物活性的天然和非天然目标分子。