Antigen-presenting and phagocytic functions of B cell subsets

B 细胞亚群的抗原呈递和吞噬功能

• 批准号: RGPIN-2015-04714
• 负责人: Stager, Simona
• 金额: $ 2.19万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589967
• 关键词: Antigen; presenting; phagocytic; functions; cell

B-cells are mostly known for their capacity to produce antibodies. However, an increasing body of literature has now shown that they may also participate in the immune response by various antibody-independent mechanisms, such as cytokine production, co-stimulation, and antigen presentation. B-cells can be divided in three different subpopulations: follicular B cells or B2 cells, innate-like marginal zone B-cells (MZB), and B1 B-cells. Follicular B cells are the most prominent B-cell subpopulation and reside in lymphoid follicles of secondary and tertiary lymphoid organs. MZB are located in the marginal zone of the spleen and are endowed with the capacity to bind immune complexes, migrate towards the splenic white pulp, and transfer antigen to follicular dendritic cells. B1 B-cells are known for their secretion of natural antibodies.

B细胞主要以产生抗体的能力而闻名。但是，越来越多的文献已经表明，它们也可能通过各种抗体独立的机制（例如细胞因子的产生，共刺激和抗原表现）参与免疫反应。 B细胞可以分为三种不同的亚群：卵泡B细胞或B2细胞，先天样的边缘区B细胞（MZB）和B1 B细胞。卵泡B细胞是最突出的B细胞亚群，驻留在继发性和第三级淋巴机构的淋巴卵泡中。 MZB位于脾脏的边际区域，并具有结合免疫复合物，朝着脾白浆中迁移并将抗原转移到卵泡树突状细胞的能力。 B1 B细胞以其天然抗体的分泌而闻名。