Role of osteogenic Menin in bone mass accumulation in vivo

成骨 Menin 在体内骨量积累中的作用

• 批准号: 350176
• 负责人: Abi Rafeh Jad
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=350176&lang=en
• 关键词: Bone; Bone Morphogenic Protein-2 (Bmp-2); Gene Knockout; Menin; Mesenchymal Stem Cell; Mouse; Osteoblast; Osteoclast; Osteoporosis; Transforming Growth Factor-B (Tgf-B)

Patients of the Multiple Endocrine Neoplasia type 1 disorder (Men1) present with tumours in endocrine and non-endocrine tissues. These patients have both copies of their Men1 gene mutated, and hence a non-functional protein product called menin.Mice gener

多内分泌肿瘤1型疾病（MEN1）的患者患有内分泌和非内分泌组织中的肿瘤。这些患者既有其Men1基因突变的副本，因此具有非功能性蛋白质产品，称为Menin.Mice Gener