Application of functional near-infrared imaging as a biomarker of injury and recovery in mild traumatic brain injury and concussion

功能性近红外成像作为轻度创伤性脑损伤和脑震荡损伤和恢复的生物标志物的应用

• 批准号: 478476-2015
• 负责人: Dunn, Jeff
• 金额: $ 6.06万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579541
• 关键词: Application; functional; near; infrared; imaging

Concussion and brain injury are now being recognized as a major health issue for Canadians. This problem may be especially severe in pediatric populations where brain injury could have life long implications and since children are more likely than adults to have persistent symptoms. In many sports, returning to activity before one is ready seems to increase the risk of further injury. We need to have a bette understanding of the actual injury and we need better tools to quantify the injury. MRI is a possibility but it will be limited by access and cost. We have discovered that regional brain communication may be impaired in brain injury and that this can be detected with a portable brain imaging system based on light. This method, functional near-infrared spectroscopy (fNIRS) can be used like MRI to detect brain activation but it can be done in a doctors office or playing field. We will expand our knowledge of brain communication as a marker of brain injury by measuring in different brain regions as well as in both pediatric and adult populations. We will improve the technology to make it more suitable for use by physicians and we will work with a Canadian company to determine if it is medically relevant and commercially viable to produce a fNIRS based concussion meter.

脑震荡和脑损伤现在被认为是加拿大人的主要健康问题。这个问题可能是 对于儿童群体来说尤其严重，因为儿童的脑损伤可能会产生终生影响，而且儿童更容易受到伤害。 比成年人更有可能出现持续症状。在许多运动中，在准备好之前返回活动的情况似乎有所增加 进一步受伤的风险。我们需要更好地了解实际伤害，并且需要更好的工具来量化伤害 受伤。 MRI 是一种可能性，但会受到准入和成本的限制。我们发现区域大脑通讯 可能会因脑损伤而受损，这可以通过基于光的便携式脑成像系统来检测。这 方法中，功能性近红外光谱 (fNIRS) 可以像 MRI 一样用于检测大脑激活，但可以在 医生办公室或运动场。我们将通过以下方式扩展我们对大脑通讯作为脑损伤标志的认识： 对不同的大脑区域以及儿童和成人进行测量。我们将改进技术 使其更适合医生使用，我们将与一家加拿大公司合作以确定其是否具有医学相关性 生产基于 fNIRS 的冲击仪在商业上是可行的。