Determining cause and effect: dynamic T cell receptor signaling during thymic selection

确定因果关系：胸腺选择过程中的动态 T 细胞受体信号传导

• 批准号: 320345
• 负责人: Melichar Heather
• 金额: $ 47.21万
• 依托单位: CIUSSS Est-de-l'Ile-de- Montral-Maisonneuve Rosemont
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=320345&lang=en
• 关键词: Negative Selection; Organotypic Culture; Positive Selection; Regulatory T Cell; T Cell Receptor Signaling; Thymus; Tissue Restricted Antigens; Two-Photon Microscopy; Negative Selection; Organotypic Culture; Positive Selection; Regulatory T Cell; T Cell Receptor Signaling; Thymus; Tissue Restricted Antigens; Two-Photon Microscopy

The immune system is composed of specialized cell types, each of which plays a unique role in combating disease. One of these cell subsets, T cells, develops in the thymus and plays an important function in recognizing, and eliminating, abnormal cells suc

免疫系统由专门的细胞类型组成，每种细胞类型都在打击疾病中起着独特的作用。这些细胞子集之一T细胞在胸腺中发展，并在识别和消除异常细胞中起重要功能