New organometallic and coordination chemistry for the formation and activation of carbon-carbon bonds

用于碳-碳键形成和活化的新型有机金属和配位化学

• 批准号: 138118-2011
• 负责人: Stryker, Jeffrey
• 金额: $ 6.19万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569312
• 关键词: New; organometallic; coordination; chemistry; formation

Transition metal organometallic chemistry plays a critical role in many sectors of chemical technology. Metal-mediated organic reactions provide much of the methodology used for the development and commercial production of commodity and fine chemicals, in all industries dependent on organic synthesis and catalysis - pharmaceuticals, agricultural chemicals, polymers, and structural materials. The proposed research program is interdisciplinary, combining inorganic and organic chemistry to understand and manipulate the principles governing transition metal organometallic reactivity and function. Our approach might be described as engineering on a molecular level: the rational design and implementation of new metal-mediated organic reactions, both stoichiometric and catalytic. Our program impacts fundamental chemistry and practical applications, advancing our understanding of organometallic reaction mechanisms and introducing new transformations into organic synthesis and catalysis. This program provides a unique intellectual environment for training creative and productive young scientists, with the command and confidence necessary to solve serious research problems. Four specific investigations are proposed, ranging from new catalyst design to new strategies for the controlled cleavage of strong carbon-carbon bonds. First, new geometrically-constrained coordination complexes will be created and exploited for catalysis, with the metal(s) in strained coordination geometries. The three other projects involve the creation of new reactions in which complex organic molecules are made in a highly controlled fashion. The first expands on investigation of metal-directed radical alkylation, using metal coordination to invert natural selectivities. In the second project, new metal-mediated cycloaddition reactions will be developed for the preparation of important carbocyclic and heterocyclic materials. The third project is focused on new metal-directed ring-expansion reactions, an unusual process in which the metal cleaves open a carbon-carbon bond and inserts in a new two-carbon unit.

过渡金属有机金属化学在化学技术的许多领域都起着至关重要的作用。 在所有依赖有机合成和催化的行业中，金属介导的有机反应提供了用于开发和商业生产的大部分方法，用于开发和商业生产 - 药物，农业化学品，聚合物和结构材料。 拟议的研究计划是跨学科的，结合了无机和有机化学，以理解和操纵有关过渡金属有机金属反应性和功能的原理。 我们的方法可能被描述为分子水平上的工程：新型金属介导的有机反应的合理设计和实施，包括化学计量和催化。 我们的计划影响了基本的化学和实际应用，促进了我们对有机反应机制的理解，并将新的转变引入有机合成和催化中。 该计划为培训创造性和富有成效的年轻科学家提供了独特的智力环境，并具有解决严重研究问题所需的指挥和信心。 提出了四项特定的研究，从新的催化剂设计到强烈碳碳键的控制裂解的新策略不等。 首先，将使用金属在紧张的协调几何形状中创建并利用新的几何结构配位络合物进行催化。 其他三个项目涉及创建新反应，其中复杂的有机分子以高度控制的方式进行。 首先使用金属配位来逆转自然选择性，以研究金属定向的自由基烷基化。 在第二个项目中，将开发新的金属介导的环加成反应，以制备重要的碳环和杂环材料。 第三个项目的重点是新的金属指导的环膨胀反应，这是一个不寻常的过程，其中金属裂解碳碳键并插入新的两碳单元中。