Light emitting diodes and pulsing systems for next generation optogenetic tools

用于下一代光遗传学工具的发光二极管和脉冲系统

• 批准号: 470349-2014
• 负责人: Woolley, Andrew
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=564096
• 关键词: Light; emitting; diodes; pulsing; systems

Mightex is a Toronto-based biophotonics company with a strong interest in the field of optogenetics. This is a new and rapidly developing field in which light is used to control genetically modified targets ("optogenetic tools") inside living animals. There is great excitement in the scientific community about the power of optogenetic approaches for understanding complex neurological diseases such as schizophrenia and autism. Mightex wishes to adapt or develop technology to keep pace with next generation optogenetic tools. The Woolley lab is developing these optogenetic tools (called "opto-drugs") for light controlled action on specific proteins in the brain. This proposal seeks to bring together researchers in the Woolley lab and engineers from Mightex to modify and optimize Mightex BioLED and Intellipusling equipment for the control of opto-drugs.

Mightex 是一家总部位于多伦多的生物光子公司，对光遗传学领域有着浓厚的兴趣。这是一个快速发展的新领域，利用光来控制活体动物体内的转基因目标（“光遗传学工具”）。科学界对光遗传学方法在理解精神分裂症和自闭症等复杂神经系统疾病方面的力量感到非常兴奋。 Mightex 希望调整或开发技术以跟上下一代光遗传学工具的步伐。伍利实验室正在开发这些光遗传学工具（称为“光药物”），用于对大脑中特定蛋白质进行光控制作用。该提案旨在将 Woolley 实验室的研究人员和 Mightex 的工程师聚集在一起，修改和优化 Mightex BioLED 和 Intellipusling 设备，以控制光药物。