The role of inhibition in the control of locomotion

抑制在运动控制中的作用

• 批准号: 356153-2013
• 负责人: Whelan, Patrick
• 金额: $ 2.4万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549932
• 关键词: role; inhibition; control; locomotion

The spinal cord contains neural circuits that can generate the basic locomotor pattern in a variety of species from primitive protovertebrates to man. While the functional architecture is well known for certain vertebrates such as lamprey and xenopus, much less is known about mammalian CPGs. What is starting to become clear is that the mutually excitatory interneurons within each hemisegment may form the kernel or unit oscillator which is interconnected with other oscillators located ipsilaterally in different segments or in the other hemisegment. Thus inhibitory drive is crucial to allow the genesis of a full repertoire of locomotor behaviors. However, we still don't have a full grasp on the role of inhibition in crafting the rhythm. Partly this is because we lack the ability to fully manipulate inhibitory drive at a segmental level.

脊髓包含神经回路，可以在各种物种中产生基本的运动模式，从原始的脂脑到人。尽管功能性结构以某些脊椎动物（例如Lamprey和Xenopus）而闻名，但对哺乳动物CPG的了解却少得多。开始变得清楚的是，每个半个子内的相互兴奋性中间神经元可能形成内核或单位振荡器，该内核或单位振荡器与其他位于不同段或另一个Hemisegment的同侧的振荡器相互关联。因此，抑制性驱动对于允许运动行为的全部曲目起源至关重要。但是，我们仍然没有完全掌握抑制在制作节奏中的作用。部分原因是我们缺乏在分段级别完全操纵抑制驱动的能力。