Genetic Analysis of Synaptic Structure and Function

突触结构和功能的遗传分析

• 批准号: 250078-2012
• 负责人: Stewart, Bryan
• 金额: $ 2.91万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547505
• 关键词: Genetic; Analysis; Synaptic; Structure; Function

Neurons are brain cells. My research addresses fundamental questions about how neurons develop and how they work. Importantly, we try to figure out how neurons process and transmit information, which is the basic function of the nervous system. Since our studies are at the level of genes, molecules, and cells all of the knowledge we create will be at the foundation of a general understanding of the brain and nervous system. We will make important contributions to understanding neural phenomenon such as locomotion, information processing, and learning & memory. In addition, many of the genes and molecules we work on have links to human disease processes. For example, one molecule we work on is linked to schizophrenia and we are developing data that may link it to cancer. Another molecule is linked to Griscelli syndrome, while yet another is implicated in May-Heglin anomaly. Altogether, our work has the potential to advance the basic understanding of neural development and function and contribute to improvements in human health by elucidating the cellular function of specific molecules.

神经元是脑细胞。我的研究解决了有关神经元如何发育及其工作原理的基本问题。重要的是，我们试图弄清楚神经元如何处理和传递信息，这是神经系统的基本功能。由于我们的研究是在基因、分子和细胞水平上进行的，因此我们创造的所有知识都将成为对大脑和神经系统的一般理解的基础。我们将为理解运动、信息处理、学习和记忆等神经现象做出重要贡献。此外，我们研究的许多基因和分子都与人类疾病过程有关。例如，我们研究的一种分子与精神分裂症有关，并且我们正在开发可能将其与癌症联系起来的数据。另一种分子与格里斯切利综合征有关，而另一种分子则与梅-赫格林异常有关。总而言之，我们的工作有潜力促进对神经发育和功能的基本理解，并通过阐明特定分子的细胞功能来促进人类健康的改善。