Catalytic carbon-carbon bond breaking and forming methods

催化碳-碳键断裂和形成方法

• 批准号: 238524-2010
• 负责人: Fillion, Eric
• 金额: $ 4.44万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547019
• 关键词: Catalytic; carbon; bond; breaking; forming

The development of catalytic methods for the formation of carbon-carbon (C-C) sigma-bonds represents a challenging and dynamic area in organic chemistry. That unremitting interest is driven by the widespread appearance of such bonds in natural and non-natural bioactive compounds. Consequently, the expedient assembly and/or modification of C-C s bond-containing targets are of broad interest and demand the development of general chemo-, diastereo-, and enantioselective methods. Carbon-carbon bond formation has proven synthetic utility in the preparation of biologically active natural products, and plays a major role in medicinal chemistry and the development of pharmaceuticals.

形成碳碳（C-C）Sigma-Bonds的催化方法的发展代表了有机化学中具有挑战性且动态的区域。这种键在天然和非天然生物活性化合物中的普遍外观驱动了这种不懈的兴趣。因此，含有C-C S键的目标的方便组装和/或修改具有广泛的兴趣，需要开发一般化学，映射和对映选择性方法。碳碳键的形成已证明在制备生物活性天然产物中的合成效用，并且在药物化学和药物的发展中起着重要作用。