Microbiome Regulation of the Host Mitochondrial Genome

宿主线粒体基因组的微生物组调控

• 批准号: FT230100513
• 负责人: A/Prof Steven Zuryn
• 金额: $ 75.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-06-29 至 2028-06-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100513
• 关键词: Microbiome; Regulation; Host; Mitochondrial; Genome

This project aims to describe newly discovered processes by which bacteria that reside in the gut of an animal influences host mitochondria, the powerhouses of the cell. Using advanced genetic and molecular methodologies, this project aims to generate new knowledge on improving mitochondrial function as well as advance our understanding of the emerging field of microbiome research. Expected outcomes include a novel and universal technology platform in which to engineer small molecules and probiotics to improve mitochondrial health and enhance fitness in a range of animals. This should provide significant benefits, through both scientifically relevant outcomes and economic benefits through technological advancements.

该项目旨在描述新发现的过程，通过这些过程，在动物的肠道中驻留的细菌会影响宿主线粒体，即细胞的动力室。该项目使用先进的遗传和分子方法，旨在生成有关改善线粒体功能的新知识，并促进我们对微生物组研究的新兴领域的理解。预期的结果包括一个新颖而通用的技术平台，在该平台中，可以在其中设计小分子和益生菌，以改善线粒体健康并增强一系列动物的适应性。通过技术进步，这应该通过科学相关的结果和经济利益提供重大利益。