Biointerface science: proteoglycan 4 (PRG4) with and without hyaluronic acid as a novel ocular surface boundary lubricant & contact lens coating

生物界面科学：含或不含透明质酸的蛋白聚糖 4 (PRG4) 作为新型眼表边界润滑剂

• 批准号: 413685-2012
• 负责人: Schmidt, Tannin
• 金额: $ 8.91万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=530815
• 关键词: Biointerface; science; proteoglycan; PRG4; without

Dry eye disease is a major health-care issue and drain on health-care resources worldwide, with symptoms of discomfort, damage to the ocular surface, and a significant reduction in quality of life, with no current therapeutically effective treatments. Cells at the ocular surface, which forms a biointerface when sliding against an opposing tissue or contact lens, are subject to significant friction forces generated with eyelid blinking. These forces can be exacerbated by contact lens wear particularly in the presence of a compromised tear film, another symptom of dry eye. Proteoglycan 4 (PRG4), also known as lubricin, is a protein originally discovered in synovial fluid and on the surface of articular cartilage that has recently been discovered at the ocular surface. PRG4 has been shown to function in a dose-dependent manner, both alone and in combination with hyaluronic

干眼症是一个主要的医疗保健问题，并且在全球范围内耗尽了医疗资源，不适感，眼表面损害以及生活质量的显着降低，目前没有治疗效果。眼表面的细胞在向相对的组织或隐形眼镜上滑动时形成生物界面，受到眼睑眨眼产生的明显摩擦力。隐形眼镜磨损，特别是在造成的撕裂膜的情况下，这是另一种干眼症的症状，可以通过隐形眼镜磨损加剧这些力。蛋白聚糖4（PRG4），也称为润滑剂，是一种蛋白质，最初是在滑液中发现的，并且在最近在眼表面发现的关节软骨表面。 PRG4已显示以剂量依赖性的方式单独并且与透明质酸结合起作用