Novel signalling motifs in macrophage patterm recognition receptors

巨噬细胞模式识别受体中的新信号基序

• 批准号: 386429-2010
• 负责人: Bowdish, Dawn
• 金额: $ 2.77万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528874
• 关键词: Novel; signalling; motifs; macrophage; patterm

Early in evolution single celled organisms developed a process called phagocytosis ("big-eating") in order to ingest food. This process was adapted for destroying competing organisms or pathogens, in essence by eating them and killing them through a process similar to digestion. In complex organisms such as ourselves, we have specialized amoeboid-like cells called macrophages that specialize in patrolling the tissues and phagocytosing/eating not only pathogens but also our own dead cells and waste products. Macrophages recognize their targets by surface bound proteins called receptors. When a macrophage encounters a potential target it must process and transmit a phenomenal amount of information including the size of the target, whether it is harmless or dangerous, and whether it can remove it or should recruit reinforcements. How it transmits this information is unclear and is the focus of this research program. This work will elucidate novel mechanisms of cellular signalling, increase our understanding on the evolution of phagocytosis and phagocytic receptors and has implications in many processes including host defence, homeostasis and embryonic development.

在进化早期，单细胞生物为了摄取食物而发展出一种称为吞噬作用（“大吃”）的过程。这个过程适用于消灭竞争的生物体或病原体，本质上是通过类似于消化的过程吃掉它们并杀死它们。在像我们这样的复杂生物体中，我们有专门的类似变形虫的细胞，称为巨噬细胞，它们专门巡逻组织，不仅吞噬/吃掉病原体，还吞噬/吃掉我们自己的死亡细胞和废物。巨噬细胞通过称为受体的表面结合蛋白识别其靶标。当巨噬细胞遇到潜在目标时，它必须处理和传输大量信息，包括目标的大小、它是无害的还是危险的、以及是否可以移除它或应该招募增援。它如何传输这些信息尚不清楚，这是本研究计划的重点。这项工作将阐明细胞信号传导的新机制，增加我们对吞噬作用和吞噬受体进化的理解，并对宿主防御、体内平衡和胚胎发育等许多过程产生影响。