Collective Molecular Dynamic in proteins and membranes

蛋白质和膜的集体分子动力学

• 批准号: 372586-2009
• 负责人: Rheinstadter, Maikel
• 金额: $ 2.04万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528550
• 关键词: Collective; Molecular; Dynamic; proteins; membranes

Even that biological membranes have been studied for decades, very few biologically relevant processes could be revealed on a molecular level. The reason is the combination of very small nanometer length scales and at the same time very fast dynamics of pico- and nanoseconds, which poses particular experimental challenges. The dynamics involve processes from fast motions of lipid molecules and small protein groups to slow conformational changes of large membrane areas and of membrane embedded proteins. Biological materials are therefore considered as "multi-scale" materials and in order to fully characterize the fluctuations experiments must cover an as large as possible range of length and time scales. This issue can only be addressed by using multiple physical techniques and instruments. We propose to combine neutron, x-ray and light scattering techniques to conduct "broadband membrane and protein spectroscopy".

即使已经研究了几十年来研究生物膜，在分子水平上几乎没有生物学相关的过程。原因是非常小的纳米长度尺度和同时非常快速的PICO和纳秒动力学的组合，这带来了特定的实验挑战。该动力学涉及从脂质分子和小蛋白质基的快速运动到缓慢膜区域和膜嵌入蛋白的构象变化的过程。因此，生物材料被认为是“多尺度”材料，为了充分表征波动实验必须覆盖尽可能较大的长度和时间尺度范围。只能通过使用多种物理技术和工具来解决此问题。我们建议将中子，X射线和光散射技术结合起来，以进行“宽带膜和蛋白质光谱”。