C. elegans p53 family transcription factor has roles in meiotic recombination and DNA interstrand crosslink repair

线虫 p53 家族转录因子在减数分裂重组和 DNA 链间交联修复中发挥作用

• 批准号: 272893
• 负责人: Mateo Abigail Rachele F
• 金额: $ 3.82万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-10-01 至 2015-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=272893&lang=en
• 关键词: Brca1; C. Elegans; Cep-1; Dna Interstrand Crosslinks; Dna Repair; Fanconi Anemia; Genomic Instability; Meiotic Recombination; P53 Family; P63

The p53 family of transcription factors (p53,p63,p73) function as tumour suppressors by promoting apoptosis, cell cycle arrest and DNA repair. Recent studies revealed that p63 and p73 promote DNA repair by transcriptionally activating components of the Fa

p53 转录因子家族 (p53、p63、p73) 通过促进细胞凋亡、细胞周期停滞和 DNA 修复发挥肿瘤抑制因子的作用。最近的研究表明，p63 和 p73 通过转录激活 Fa 的成分来促进 DNA 修复