Molecular diversity from naphthalene nucleus

萘核的分子多样性

• 批准号: 261684-2010
• 负责人: Jha, Amitabh
• 金额: $ 2.19万
• 依托单位: Acadia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525331
• 关键词: Molecular; diversity; naphthalene; nucleus

All aspects of applied organic chemistry rely on the ability to generate a vast variety of novel molecular architectures with interesting properties. This places a persistent demand on the synthetic organic chemists to develop and fine-tune various procedures that enable the synthesis of the desired structural frameworks. The research laboratory of the applicant has actively been involved in the synthesis of novel molecular frameworks from naphthalene nucleus over the past several years. Building on this evolving expertise, the applicant plans to continue devising practical synthetic routes to construct an array of important novel molecular frameworks, from naphthalene core, having a variety of molecular topology and functional groups. The putative synthetic designs will lead to synthesis of a selection of quasi-steroids and novel naphthalene-based oxacycles in addition to the development of several practical synthetic methodologies for important organic transformations. Asymmetric synthesis will be undertaken employing chiral induction through catalysis. The specific target skeletons selected for this investigation are expected to possess a wide variety of topologies and properties. Wherever possible studies will be undertaken to unravel any interesting spectroscopic and electronic properties of the molecules synthesized. Attempts will also be made to make the library of compounds synthesized available to fellow scientists with complementary expertise to study their potential as pharmaceuticals, catalysts, photocages, fluorophores, etc. During the tenure of this grant, ~8 graduate students and ~20 advanced undergraduate students will receive high quality training in the art of organic synthesis and scientific writing among other research related skills. In addition to imparting intensive HQP training, this endeavor will lead to new knowledge in the field of methodology development in general and in the area of quasi-steroid and o-naphthoquinone methide generation and application in particular. The medicinal chemistry community working on the development of quasi-steroidal drugs (and ultimately human health) will benefit from the outcome of the proposed research.

应用有机化学的各个方面都依赖于生成各种具有有趣特性的新颖分子结构的能力。这对合成有机化学家提出了持续的要求，以开发和微调各种程序，以合成所需的结构框架。申请人的研究实验室在过去几年中积极参与从萘核合成新型分子骨架。基于这种不断发展的专业知识，申请人计划继续设计实用的合成路线，以从萘核心构建一系列重要的新型分子框架，具有各种分子拓扑和官能团。除了开发几种用于重要有机转化的实用合成方法之外，假定的合成设计还将导致一系列类固醇和新型萘基氧杂环化合物的合成。不对称合成将通过催化采用手性诱导进行。本次研究选择的特定目标骨架预计将具有多种拓扑结构和特性。只要有可能，我们都会进行研究，以揭示合成分子的任何有趣的光谱和电子特性。还将尝试将合成的化合物库提供给具有互补专业知识的科学家同事，以研究它们作为药物、催化剂、光笼、荧光团等的潜力。在这笔资助期间，约 8 名研究生和约 20 名高级本科生学生将接受有机合成艺术和科学写作以及其他研究相关技能的高质量培训。除了传授密集的 HQP 培训外，这项工作还将带来一般方法开发领域的新知识，特别是类固醇和邻萘醌甲基化物的生成和应用领域的新知识。致力于开发类甾体药物（并最终促进人类健康）的药物化学界将受益于拟议研究的成果。