Mechanisms underlying the trophic and chemotropic effects of retinoic acid

视黄酸的营养和趋化作用的机制

• 批准号: 238373-2010
• 负责人: Spencer, Gaynor
• 金额: $ 4.66万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=524306
• 关键词: Mechanisms; underlying; trophic; chemotropic; effects

My research program focusses on how nerve cells extend their processes during development and nerve regeneration and then form connections with appropriate partner cells. To this end, I use the large identifiable nerve cells of the adult mollusc, Lymnaea stagnalis, which can regenerate in cell culture. At the growing ends of regenerating neurites, structures known as growth cones are found. These structures are responsible for pathfinding during nervous system development and regeneration, and then selecting and forming appropriate connections with target cells.

我的研究项目重点关注神经细胞在发育和神经再生过程中如何扩展其过程，然后与适当的伙伴细胞形成连接。为此，我使用了成年软体动物 Lymnaea stagnalis 的大型可识别神经细胞，它们可以在细胞培养中再生。在再生神经突的生长末端，发现了称为生长锥的结构。这些结构负责神经系统发育和再生过程中的寻路，然后选择并与靶细胞形成适当的连接。