The role of FGF23 in fetal phosphorus metabolism

FGF23在胎儿磷代谢中的作用

• 批准号: 259633
• 负责人: Kovacs Christopher S
• 金额: $ 12.88万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-03-01 至 2015-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=259633&lang=en
• 关键词: Fetal Mineral Metabolism; Fetal-Placental Mineral Transport; Fgf23; Phex; Phosphorus Metabolism; Sodium-Phosphate Cotransporter; Vitamin D/Calcitriol; X-Linked Hypophosphatemic Rickets

Phosphorus initiates critical steps in the formation of the skeleton and in its subsequent mineralization; without phosphorus, calcium cannot bind, and the skeleton is deformed and weak (rickets or osteomalacia). Recently fibroblast growth factor-23 (FGF2

磷在骨骼的形成及其随后的矿化中启动了关键步骤。如果没有磷，钙就无法结合，骨骼变形且弱（rick骨或骨软骨）。最近成纤维细胞生长因子23（FGF2