Single-nanostructure spectroscopy for optical characterization of discrete nanostructures and their development as miniaturized sensors and bioanalytical tools

用于离散纳米结构光学表征的单纳米结构光谱及其作为微型传感器和生物分析工具的开发

• 批准号: 439752-2013
• 负责人: Chen, JenniferILing
• 金额: $ 7.04万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=507074
• 关键词: Single; nanostructure; spectroscopy; optical; characterization

Our research program aims to explore biomolecular-mediated plasmonic assemblies for applications such as sensing and solar energy conversion. Plasmonics are actively pursued for a wide range of technological applications including biomedical imaging, optoelectronics, telecommunications and sensing, in which the morphology and organization of the nanostructures underpins the plasmon-enhanced effects. Conventional bulk optical characterization techniques probe an ensemble of nanostructures and therefore suffer from effects of sample inhomogeneity and spectral broadening. Techniques for measuring optical properties at the single nanostructure level are therefore invaluable for elucidating the electromagnetic interactions. Our research aims to use single-nanostructure spectroscopy to investigate plasmon coupling in discrete biomolecular-linked multi-nanoparticle assemblies. The requested spectroscopic setup will be used to characterize and guide the design of these dynamic nanostructures for achieving unconventional spectral response that can provide new capabilities in sensing. Potential advances in sensing include the ability to detect analytes in real samples without purification and the development nano optical sensors for high-density multiplexed arrays and for quantitative analysis of local chemical environment in cellular processes. The requested equipment will be instrumental for developing new bioanalytical tools that may benefit biomedial research in Canada, and for advancing fundamental research in plasmonics. This characterization technique will provide an excellent training ground for undergraduate and graduate students in optical spectroscopy, instrument integration and scientific programming in addition to their studies on chemical and biological interactions.

我们的研究计划旨在探索用于传感和太阳能转化等应用的生物分子介导的等离子组件。在广泛的技术应用中，积极追求血浆，包括生物医学成像，光电，电信和感应，其中纳米结构的形态和组织基于等离子体增强的效果。常规的体积光学特征技术探测了纳米结构的集合，因此遭受了样品不均匀性和光谱宽的影响。因此，用于阐明电磁相互作用的单纳米结构水平上光学性质的技术是无价的。我们的研究旨在使用单纳米结构光谱法研究离散生物分子链接多纳米颗粒组件中的等离子体耦合。请求的光谱设置将用于表征和指导这些动态纳米结构的设计，以实现非常规光谱响应，可以为传感提供新的功能。传感的潜在进步包括在没有纯化的情况下检测实际样品中分析物的能力以及用于高密度多重阵列的纳米光学传感器以及对细胞过程中局部化学环境的定量分析。所需的设备将有助于开发新的生物分析工具，这些工具可能使加拿大的生物医学研究受益，并推进血浆基础研究的基础研究。这种表征技术还将为学科和研究生提供良好的培训理由，除了他们对化学和生物学相互作用的研究外，还将在光谱，仪器整合和科学编程中进行良好的培训。