Control of mesoderm involution during gastrulation

原肠胚形成过程中中胚层复旧的控制

• 批准号: 250201-2012
• 负责人: Winklbauer, Rudolf
• 金额: $ 1.89万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505704
• 关键词: Control; mesoderm; involution; during; gastrulation

The body plan of animals and humans is established in early embryonic development by a series of tissue movements, which are collectively referred to as gastrulation. During gastrulation, cells that will later form the inner organs of the body move from the surface to the interior of the embryo.Dr. Winklbauer's research group studies how this movement is controlled in a model organism, the frog Xenopus laevis. Interestingly, genes that are involved in regulating gastrulation are also activated when the embryonic skin is wounded, suggesting a link between wound healing processes and embryonic tissue movements that could lead to important biomedical discoveries.

动物和人类的身体规划是在胚胎发育早期通过一系列组织运动建立的，这些运动统称为原肠胚形成。在原肠胚形成过程中，随后形成体内器官的细胞从胚胎表面移动到内部。 Winklbauer 的研究小组研究了这种运动是如何在模式生物（非洲爪蟾）中控制的。有趣的是，当胚胎皮肤受伤时，参与调节原肠胚形成的基因也会被激活，这表明伤口愈合过程和胚胎组织运动之间存在联系，这可能会带来重要的生物医学发现。