Conformational changes of the HIV-1 envelope glycoproteins: a structural/functional approach to understand the transition to the CD4-bound conformation and identify new therapeutic targets

HIV-1 包膜糖蛋白的构象变化：一种结构/功能方法，用于了解向 CD4 结合构象的转变并确定新的治疗靶点

• 批准号: 237665
• 负责人: Finzi Andrs
• 金额: $ 36.73万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=237665&lang=en
• 关键词: Env Gps Conformational Changes; Gp120; Gp120 Cd4-Bound Conformation; Gp120-Gp41 Interaction; Gp41; Hiv; Isotermal Calorimetry; New Inhibitors Of Hiv Fusion; Surface Plasmon Resonance; Viral Replication

In the absence of treatment, human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), which has already killed more than 33 million people worldwide. To be able to spread, HIV needs first to enter human cells. To do so, HIV h

在没有治疗的情况下，人类免疫缺陷病毒（HIV）导致获得的免疫缺陷综合征（AIDS），该综合征已经杀死了全球超过3300万人。 为了能够传播，艾滋病毒需要首先进入人类细胞。 为此，HIV H