Finding the targets of natural products in complex botanical extracts.

寻找复杂植物提取物中天然产物的靶标。

• 批准号: LP230100225
• 负责人: Prof David Adelson
• 金额: $ 31.04万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP230100225
• 关键词: Finding; targets; natural; products; complex

Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify the molecular targets of many compounds in complex plant extracts, along with their subsequent validation by responses in gene expression to the plant extract. This research will revolutionise understanding of the nutritional and medicinal effects of plants and will allow our partners to accelerate commercialisation.

许多植物用于营养和传统医学目的，并证明了基于证据的影响。但是，识别负责观察到效应的单个化学化合物的标准方法失败，因为它们依赖于具有单个靶标的单个化合物，而忽略了许多相互作用化合物对许多靶标的总体影响。在此应用中，我们提出了一种新方法，以同时识别复杂植物提取物中许多化合物的分子靶标，以及随后通过基因表达对植物提取物的反应的验证。这项研究将彻底改变人们对植物的营养和药物影响的理解，并使我们的合作伙伴能够加速商业化。