Understanding and preventing secondary degeneration following CNS injury

了解和预防中枢神经系统损伤后的继发性变性

• 批准号: nhmrc : 572550
• 负责人: Prof Melinda Fitzgerald
• 金额: $ 27.28万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-preventing-secondary-cns-injury/76744
• 关键词: Understanding; preventing; secondary; degeneration; following

After neurotrauma, tissue escaping initial injury undergoes secondary degeneration; tissue loss spreads, function worsens. In the complex brain and spinal cord it is difficult to distinguish vulnerable tissue. Using the visual system as a model I will precisely identify cells and processes of secondary degeneration, determine if vulnerable tissue can be rescued by drugs stopping toxic calcium influx and if rescued circuits work properly. The work has implications for neurotrauma and glaucoma.

神经外伤后，逃脱初始损伤的组织会发生继发性变性；组织损失扩大，功能恶化。在复杂的大脑和脊髓中，很难区分脆弱的组织。使用视觉系统作为模型，我将精确识别细胞和继发性变性的过程，确定是否可以通过阻止有毒钙流入的药物来挽救脆弱的组织，以及挽救的电路是否正常工作。这项工作对神经外伤和青光眼具有重要意义。