Targeting the Plasmodium falciparum Metalloaminopeptidases for Development of New Antimalarial Agents

针对恶性疟原虫金属氨基肽酶开发新型抗疟药物

• 批准号: nhmrc : 1063786
• 负责人: Dr Sheena Mcgowan
• 金额: $ 37.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-plasmodium-falciparum-antimalarial-agents/455084
• 关键词: Targeting; Plasmodium; falciparum; Metalloaminopeptidases; Development

Each year 1-2 million people will die from malaria. The prevention and treatment of malaria is becoming increasingly difficult due to the spread of drug-resistance. There is an urgent need for next generation of antimalarials with new modes of action. This project will develop new antimalarial agents against the malarial aminopeptidase drug targets.

每年有1-200万人死于疟疾。由于抗药性的扩散，疟疾的预防和治疗变得越来越困难。迫切需要采用新的作用方式的下一代抗疟疾。该项目将开发针对疟疾氨基肽酶药物靶标的新抗疟疾剂。