Precise, Cytosolic Dendrimer Delivery Systems

精确的细胞质树枝状聚合物输送系统

• 批准号: LP230100282
• 负责人: A/Prof Angus Johnston
• 金额: $ 39.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP230100282
• 关键词: Precise; Cytosolic; Dendrimer; Delivery; Systems

This project aims to use precisely targeted dendrimer technology to improve the delivery of poorly permeable molecules to their subcellular sites of action. Our cutting edge approach combines innovative phage screening techniques and advanced dendrimer synthesis. The outcomes of this proposal will be: 1) a targeting system that is manufacturable at scale and reasonable cost, 2) a dendrimer delivery system that is rapidly internalised into specifc target cells and 3) bio-responsive dendrimers that promote delivery of their cargo into the cytosol. This work will strengthen a highly successful collaboration between the Australian biotech company Starpharma and Monash University, to design the next generation of nanomaterials delivery systems.

该项目旨在利用精确靶向的树枝状聚合物技术来改善渗透性差的分子向其亚细胞作用位点的递送。我们的尖端方法结合了创新的噬菌体筛选技术和先进的树枝状聚合物合成。该提案的成果将是：1）可大规模生产且成本合理的靶向系统，2）可快速内化到特定靶细胞中的树枝状聚合物递送系统，3）促进将其货物递送至特定靶细胞的生物响应性树枝状聚合物。细胞质。这项工作将加强澳大利亚生物技术公司 Starpharma 和莫纳什大学之间非常成功的合作，以设计下一代纳米材料输送系统。