Dissecting the heterogeniety of human tissue-resident memory T cells

剖析人体组织驻留记忆 T 细胞的异质性

• 批准号: DE240101101
• 负责人: Dr Claire Gordon
• 金额: $ 31.36万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2029-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240101101
• 关键词: Dissecting; heterogeniety; human; tissue; resident

Tissue-resident memory T cells (TRM) are key to immune protection against infection and cancer, yet dysfunctional TRM cause autoimmune disease. Whilst much of our understanding of TRM comes from animal models, how these cells work in humans is largely unknown. This project aims to define the phenotypic, functional and regulatory heterogeneity of human TRM subsets in organs like the gut, liver, and skin using a unique human organ donor tissue resource. The expected outcomes are to generate fundamental new knowledge that will have significance for the development of new therapies against infectious diseases, cancer and autoimmunity.

组织驻留记忆 T 细胞 (TRM) 是免疫保护免受感染和癌症的关键，但功能失调的 TRM 会导致自身免疫性疾病。虽然我们对 TRM 的了解大部分来自于动物模型，但这些细胞如何在人体中发挥作用尚不清楚。该项目旨在利用独特的人类器官供体组织资源，定义肠道、肝脏和皮肤等器官中人类 TRM 子集的表型、功能和调控异质性。预期结果是产生基本的新知识，这对于开发针对传染病、癌症和自身免疫的新疗法具有重要意义。