Safety of Hendra virus anti-G glycoprotein monoclonal antibody in humans

亨德拉病毒抗 G 糖蛋白单克隆抗体在人体内的安全性

• 批准号: nhmrc : 1041833
• 负责人: A/Pr E Geoffrey Playford
• 金额: $ 26.67万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/safety-hendra-virus-antibody-humans/111400
• 关键词: Safety; Hendra; virus; anti; glycoprotein

Hendra virus infection in humans is a serious, and often fatal, disease. No cure exists for Hendra infection and existing treatments are ineffective. Recently, a human monoclonal antibody has shown great promise in protecting animals from developing the disease. This project aims to perform preclinical safety testing and a Phase I clinical trial to establish the safety profile of this antibody such that it can be used to prevent Hendra infection in humans exposed to the disease.

人类感染亨德拉病毒是一种严重且常常致命的疾病。亨德拉感染尚无治愈方法，现有治疗方法也无效。最近，一种人类单克隆抗体在保护动物免受这种疾病方面显示出巨大的前景。该项目旨在进行临床前安全性测试和一期临床试验，以确定该抗体的安全性，使其可用于预防接触该疾病的人类感染亨德拉病毒。