The role of the Ras signalling molecule, C3G, in the interaction of neural precursor cells and their environment

Ras 信号分子 C3G 在神经前体细胞与其环境相互作用中的作用

• 批准号: nhmrc : 461215
• 负责人: A/Pr Anne Voss
• 金额: $ 21.3万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ras-signalling-cells-environment/101506
• 关键词: role; Ras; signalling; molecule; C3G

Developmental brain disorders affect 1-3% of the population. The mental retardation disease spectrum includes neuronal migration disorders and neural precursor proliferation disorders. We propose to study a molecular mechanism regulating neuronal migration, survival and proliferation. We have identified a protein, C3G, which is essential for three aspects of nervous system development: (A) C3G limits neural precursor cell proliferation. (B) C3G is essential for neuronal survival. (C) C3G is crucial for neuronal migration. C3G acts in a cascade of proteins, known as the Ras signalling pathway, which transmits signals from the extracellular environment into the cell nucleus to elicit appropriate responses of the cell to cues from the outside. We will identify proteins that, together with C3G, affect the important processes of neural precursor proliferation, and neuron survival and migration. This project will fully characterise a key regulatory mechanism of cellular processes crucial to the development of normal intelligence.

发育性脑部疾病会影响1-3％的人群。智力低下的疾病谱包括神经元迁移障碍和神经前体增殖疾病。我们建议研究调节神经元迁移，存活和增殖的分子机制。我们已经确定了一种蛋白质C3G，这对于神经系统发育的三个方面至关重要：（a）C3G限制了神经前体细胞的增殖。 （b）C3G对于神经元生存至关重要。 （c）C3G对于神经元迁移至关重要。 C3G作用于一系列蛋白质（称为RAS信号途径）中，该蛋白质将信号从细胞外环境传输到细胞核中，从而引起细胞对从外部提示的适当反应。我们将确定蛋白质与C3G一起影响神经前体增殖的重要过程以及神经元的生存和迁移。该项目将充分表征细胞过程的关键调节机制，对正常智力的发展至关重要。