Developing the toolbox of compounds that target acid-sensing proteins

开发针对酸敏蛋白的化合物工具箱

• 批准号: DE240101233
• 负责人: Dr Ben Cristofori-Armstrong
• 金额: $ 30.97万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240101233
• 关键词: Developing; toolbox; compounds; target; acid

This project aims to examine the interaction between acid-sensing proteins and their modulatory compounds. Animals, including humans, must sense changes in environmental acidity to successfully interact with the surrounding world. Expected outcomes of the project include a better understanding of which regions of these proteins detect acidity, and to develop new compounds that modulate the proteins’ function. This would advance our fundamental knowledge in the physiological process of acid sensing. This expects to provide significant benefits, by aiding the potential development of agrochemicals and pain-relieving medications that regulate acid-sensing protein function, resulting in economic benefit to Australia via these new products.

该项目旨在检查酸敏蛋白及其调节化合物之间的相互作用。包括人类在内的动物必须感知环境酸度的变化，以成功与周围世界相互作用。该项目的预期结果包括更好地了解这些蛋白质的哪些区域检测酸度，并开发调节蛋白质功能的新化合物。这将提高我们在酸感测的物理过程中的基本知识。这希望通过协助农业化学物质的潜在发展和促疼痛的药物来调节酸敏感蛋白功能，从而通过这些新产品为澳大利亚带来经济利益，从而提供重大的好处。