Optical Metasurface for Single Small Extracellular Vesicle Analysis

用于单个小细胞外囊泡分析的光学超表面

• 批准号: DE240100321
• 负责人: Dr Ying Zhu
• 金额: $ 31.16万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100321
• 关键词: Optical; Metasurface; Single; Small; Extracellular

This project aims to develop an innovative nanobiotechnology to study small extracellular vesicles (sEVs) – small biological particles that are important in intercellular communication. The technology will enable unprecedented depth of analysis and single particle resolution. It will generate new knowledge in both engineering and biological sciences by improving sEV image resolution and collecting information regarding the distribution of different sEV subpopulations based on their protein phenotypes. Expected outcomes include a universal and ultrasensitive platform with many applications in analytical biochemistry such as disease diagnostics, environmental sciences, food safety and agriculture.

该项目旨在开发一种创新的纳米生物技术来研究小细胞外囊泡（sEV）——对细胞间通讯至关重要的小生物颗粒，该技术将实现前所未有的深度分析和单颗粒分辨率，它将产生工程和生物学方面的新知识。通过提高 sEV 图像分辨率并根据其蛋白质表型收集有关不同 sEV 亚群分布的信息，预期成果包括一个通用且超灵敏的平台，可在分析生物化学（例如疾病诊断、环境）方面具有许多应用。科学、食品安全和农业。