Towards a molecular fingerprint for human-specific endogenous retroviruses

人类特异性内源性逆转录病毒的分子指纹

• 批准号: DE240100707
• 负责人: Dr Dezerae Cox
• 金额: $ 31.26万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100707
• 关键词: Towards; molecular; fingerprint; human; specific

This project aims to understand how ancient viral sequences resident in the human genome can contribute to cellular processes. Using a novel molecular toolbox that combines affinity-directed proximity labelling mass spectrometry and single molecule microscopy, this project will characterise the cellular fingerprint of a human endogenous retrovirus family HERV-K (HML-2). This fingerprint will comprehensively describe how expressed HERV-K loci engage with the homeostasis network in human cells. This will provide significant benefits in the form of new knowledge concerning fundamental aspects of cellular homeostasis, and a state-of-the-art molecular biology toolbox ready to explore quantitatively the role of HERV-K in human health and disease.

该项目旨在了解人类基因组中的古代病毒序列如何促进细胞过程。该项目将使用结合了亲和定向邻近标记质谱和单分子显微镜的新型分子工具箱来表征人内源性逆转录病毒家族 HERV-K (HML-2) 的细胞指纹。该指纹将全面描述 HERV-K 基因座的表达如何与人类细胞的稳态网络相结合。这将以有关细胞稳态基本方面的新知识和最先进的分子生物学工具箱的形式提供显着的好处，以定量探索 HERV-K 在人类健康和疾病中的作用。