Collaboratory of AIDS Researchers for Eradication (CARE)

艾滋病根除研究人员合作实验室（CARE）

基本信息

批准号：
9190915
负责人：
DAVID M. MARGOLIS
金额：
$ 459.3万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-14 至 2021-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9190915
关键词：
Acquired Immunodeficiency Syndrome Adenoviruses Affinity Animal Model Antibodies Antigens Area Back Basic Science Biological Assay Biological Markers Biological Models CD4 Positive T Lymphocytes Cells Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Contracts Detection Development Disease Drug Industry Epigenetic Process Exposure to Generations Goals HIV HIV-1 Human Immune system Immunologic Deficiency Syndromes Immunotherapy In Vitro Individual Infection Interphase Cell Intervention Kinetics Knowledge Laboratory Research Lead Life Measures Medicine Modality Modified Vaccinia Virus Ankara National Institute of Allergy and Infectious Disease Pan Genus Patients Peptides Pharmacologic Substance Pilot Projects Population Process Reagent Regimen Research Research Infrastructure Research Personnel Residual state Science Scientist T-Lymphocyte Technology Testing Therapeutic Time Tissues Translating Translational Research Universities Ursidae Family Viral Antigens Viral Proteins Viral reservoir Virus Diseases Virus Latency Work abstracting antiretroviral therapy arm base collaboratory combat feeding improved in vivo industry partner inhibitor/antagonist innovation insight mortality next generation novel novel strategies pandemic disease pre-clinical prevent programs protein expression research clinical testing research study screening skills success tool vector vaccine

项目摘要

Abstract Despite the clinical success of antiretroviral therapy (ART), more people contract human immunodeficiency virus (HIV) infection daily than initiate ART. Since its inception in 2011, the Martin Delaney Collaboratory program has made important advances towards a cure for HIV, a much-needed effort to comprehensively combat the AIDS pandemic. The 2016 scientific agenda of the Collaboratory of AIDS Researchers for Eradication (CARE) seeks to more rapidly advance approaches for latency disruption and clearance into clinical testing. We hypothesize that the latent state of HIV can be reversed such that antigenic viral proteins are expressed, and that this intervention must be strategically combined with immunotherapies to allow the clearance of cells emerging from latency. Effective implementation of this strategy is expected to lead to the eradication of persistent HIV infection, a cure for AIDS. Our group now possesses substantial expertise previously not brought to bear on this problem, including the skills and tools of an expanded group of pharmaceutical partners. Our initial efforts will focus on the key objectives to facilitate clinical trials of eradication therapy: Detection of HIV antigen-positive cells (IRF I), Clearance of HIV antigen-positive cells (IRF II), Revealing and Clearing Unseen HIV (IRF 3). We envision an iterative process with insights gained in ex vivo, pre-clinical and clinical experiments carried forward to enhance the next step in clinical development and, importantly, fed back to scientists to refine their work, validate assays or hypotheses, and explore new directions. We are dedicated to working together in a nimble program, able to alter the course of our research as directed by our discoveries, convinced that together we will catalyze advances that will ultimately lead to the eradication of HIV infection.

抽象的尽管抗逆转录病毒疗法（ART）在临床上取得了成功，但仍有更多人感染人类病毒每天预防免疫缺陷病毒 (HIV) 感染，而不是开始 ART。自 2011 年成立以来，马丁·德莱尼 (Martin Delaney) 合作项目在治愈艾滋病毒方面取得了重要进展，这是一项急需的努力全面抗击艾滋病疫情。艾滋病合作实验室2016年科学议程根除研究人员 (CARE) 寻求更快速地推进延迟中断和进入临床测试的许可。我们假设 HIV 的潜伏状态可以被逆转，从而使抗原病毒蛋白得到表达，这种干预措施必须与免疫疗法战略性地结合起来允许清除潜伏期出现的细胞。该战略的有效实施预计将导致根除持续的艾滋病毒感染，治愈艾滋病。我集团现拥有大量以前没有用于解决这个问题的专业知识，包括扩大的小组的技能和工具制药合作伙伴。我们最初的努力将集中于促进临床试验的关键目标根除治疗：检测HIV抗原阳性细胞（IRF I）、清除HIV抗原阳性细胞（IRF II)，揭示和清除看不见的艾滋病毒（IRF 3）。我们设想一个迭代过程，其中包含在离体、临床前和临床实验中获得的见解继续推进临床开发的下一步，重要的是，反馈给科学家完善他们的工作，验证分析或假设，并探索新的方向。我们致力于工作一起在一个灵活的计划中，能够根据我们的发现改变我们的研究进程，确信我们将共同推动取得进展，最终消除艾滋病毒感染。