Comprehensive Genomics Shared Facility

综合基因组学共享设施

基本信息

批准号：
9296323
负责人：
MICHAEL R CROWLEY
金额：
$ 0.87万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9296323
关键词：
Animal Model Bacterial Genome Basic Science Biological Assay Biotechnology CSF3 gene Cancer Center Cancer cell line ChIP-seq Clinic Clinical Clinical Research Comprehensive Cancer Center Consult Consultations Custom DNA DNA Sequence Data Data Analyses Data Set Development Dideoxy Chain Termination DNA Sequencing Environment Equipment Genes Genetic Genomics Genotype Gnotobiotic Goals Grant Homeostasis Human Cell Line Human body Individual Institutes Investments Malignant Neoplasms Metabolism Metagenomics Methodology MicroRNAs Microarray Analysis Mission Mitochondria Molecular Molecular Analysis Molecular Biology Molecular Conformation Neoplasm Metastasis Patients Population Process Production Provider Recommendation Research Research Design Research Personnel Resources Ribosomes Running SNP genotyping Sampling Services Site Technology Translational Research abstracting anticancer research arm cancer genomics cancer type cell type clinical sequencing cost design exome experimental analysis gene cloning genetic technology genome sequencing genomic platform genomic tools human genome sequencing instrument member microbial microbiome mutation screening next generation next generation sequencing personalized medicine precision medicine research study tool transcriptome sequencing tumor whole genome

项目摘要

MOLECULAR ANALYSIS / TRANSLATION RESEARCH GROUP COMPREHENSIVE GENOMICS SHARED FACILITY (CGSF) ABSTRACT The goal of the Comprehensive Genomics Shared Facility (CGSF) is to provide Cancer Center investigators access to cutting-edge genomic resources and methodologies designed to facilitate and strengthen the quality of genetic, genomic, and molecular studies in cancer related research. The Comprehensive Genomics Shared Facility accomplishes this goal through two interrelated components: the on campus UAB Next-Generation and Sanger Sequencing (NGSS) arm, and the HudsonAlpha Institute for Biotechnology (HAIB) Next-Generation and Clinical Sequencing arm. This arrangement provides UAB Cancer Center members unprecedented access to state-of-the-art technologies for genetic and genomic analysis for basic research and clinical studies. Each component brings valuable resources to center members. The NGSS provides onsite consultation and service for various projects that require different types of genomic technologies. These include standard Sanger sequencing, human cell line identification (including cancer cell lines), SNP genotyping assays and Next-Generation Sequencing services (RNA-Seq, ChIP-Seq, microRNA-Seq, Exome-Seq, Custom amplicons, Microbiome, Metagenomics, and mitochondrial sequencing). The HAIB component offers very high throughput services for production-level whole genome sequencing and support for development and routine processing of clinical samples that require or benefit from a CLIA environment. The CGSF supports basic researchers investigating the mechanisms of cancer development, progression and metastasis as well as clinical researchers pursuing precision medicine approaches and provides the tools they need to efficiently and effectively contribute significant findings to the field of cancer research.

分子分析/翻译研究组综合基因组共享设施 (CGSF) 抽象的综合基因组共享设施 (CGSF) 的目标是为癌症中心研究人员提供获得旨在促进和加强质量的尖端基因组资源和方法癌症相关研究中的遗传、基因组和分子研究。综合基因组共享该设施通过两个相互关联的组成部分来实现这一目标：校园内的 UAB 下一代和桑格测序 (NGSS) 臂和 HudsonAlpha 生物技术研究所 (HAIB) 下一代和临床测序臂。这一安排为 UAB 癌症中心成员提供了前所未有的获得用于基础研究和临床研究的最先进的遗传和基因组分析技术。每个组件都为中心成员带来了宝贵的资源。 NGSS提供现场咨询和为需要不同类型基因组技术的各种项目提供服务。这些包括标准桑格测序、人类细胞系鉴定（包括癌细胞系）、SNP 基因分型测定和下一代测序服务（RNA-Seq、ChIP-Seq、microRNA-Seq、Exome-Seq、定制扩增子、微生物组、宏基因组学和线粒体测序）。 HAIB 组件提供非常高的吞吐量生产级全基因组测序服务以及开发和常规处理支持需要或受益于 CLIA 环境的临床样本。 CGSF 支持基础研究人员研究癌症发生、进展和转移的机制以及临床研究人员追求精准医学方法，并提供他们所需的工具，以有效和有效地为癌症研究领域贡献了重要的发现。