Full Project II: The Betel Nut Intervention Trial (BENIT)

完整项目 II：槟榔干预试验 (BENIT)

• 批准号: 9163114
• 负责人: Yvette C Paulino
• 金额: $ 12.39万
• 依托单位: UNIVERSITY OF GUAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9163114
• 关键词: Abstinence; Alcohols; Alkaloids; Areca; Asia; Behavioral; Biological Markers; Caffeine; Cancer Center; Carcinogens; Consumption; Data; Disease; Esophagus; Feasibility Studies; Fibrosis; Guam; Hawaii; Hour; International Agency for Research on Cancer; Intervention; Intervention Trial; Laboratories; Malignant neoplasm of pharynx; Mastication; Measures; Modeling; Nicotine; Nuts; Oral Leukoplakia; Outcome; Pacific Islands; Pamphlets; Participant; Patient Self-Report; Pilot Projects; Preparation; Prevalence; Randomized; Research; Saliva; Salivary; Sampling; Smoker; Southeastern Asia; Specific qualifier value; Study Section; Surveys; Testing; Treatment Efficacy; Universities; abstracting; base; carcinogenicity; efficacy testing; follow-up; liquid chromatography mass spectrometry; malignant mouth neoplasm; malignant oropharynx neoplasm; oral lesion; programs; psychologic; smoking cessation

Project Summary/Abstract Areca nut, also known as betel nut, is the fourth most commonly consumed psychoactive substance in the world, following only alcohol, nicotine, and caffeine in prevalence of consumption. Although betel nut is chewed by approximately 600 million people globally, its use is concentrated in South Asia, Southeast Asia, and some Pacific islands. Betel nut has been classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Betel nut chewing has been associated with oral and oropharyngeal cancer, oral lesions, oral leukoplakia, submucous fibrosis, gum disease, and cancer of the pharynx and esophagus. Despite the global significance and carcinogenicity of betel nut, there has been very little behavioral or psychological research about betel nut chewing, and there has been no systematic research on the topic of betel nut cessation interventions. The proposed research builds directly upon our prior research. Our survey data suggest that betel nut chewers, like smokers, generally want and intend to quit, but do not have specific plans of how or when they will quit. In addition, most betel nut chewers in our sample already have tried to quit on one or more occasions. These findings suggest that betel nut chewers could benefit from cessation programs modeled after smoking cessation programs. During 2014, we conducted a feasibility study of our betel nut cessation program. The program was well received and yielded surprisingly high rates of self- reported betel nut cessation. Our primary aim is to test the efficacy of an intensive group-based betel nut cessation program. Betel nut cessation will be bio-verified by employing biomarkers developed in our previous research. Participants (n=324) will be betel nut chewers from Guam and Saipan who are willing to attempt to quit chewing. Participants will be randomly assigned either to an intensive intervention condition or to a minimal intervention control condition. Participants in the intervention condition will receive a group-based cessation program consisting of five hour-long sessions over the span of 22 days, as well as a brochure with advice about quitting betel nut. Participants in the control condition will receive a brochure with advice about quitting betel nut. The proposed intervention trial will allow us to assess the 1-month and 6-month efficacy of the intervention compared to a minimal control intervention. We hypothesize that the intensive betel nut cessation intervention will produce a significantly greater cessation rate compared to the minimal control condition at the 6-month follow-up assessment.

项目概要/摘要 槟榔，也称为槟榔，是第四大最常食用的精神活性物质 世界范围内，消费流行率仅次于酒精、尼古丁和咖啡因。虽然嚼槟榔 全球约有 6 亿人使用它，主要集中在南亚、东南亚和一些地区 太平洋岛屿。槟榔已被国际癌症研究机构列为第一类致癌物 癌症研究。咀嚼槟榔与口腔癌和口咽癌、口腔病变、 口腔白斑、粘膜下纤维化、牙龈疾病、咽癌和食管癌。 尽管槟榔具有全球重要性和致癌性，但人们对槟榔的行为或行为却知之甚少。 关于嚼槟榔的心理学研究，目前还没有系统的研究 槟榔戒断干预措施。拟议的研究直接建立在我们之前的研究基础上。我们的调查 数据表明，咀嚼槟榔的人与吸烟者一样，普遍希望并打算戒烟，但没有具体的戒烟方案 他们如何或何时戒烟的计划。此外，我们样本中的大多数嚼槟榔者已经尝试戒烟 一次或多次。这些发现表明，嚼槟榔者可以从戒烟中受益 以戒烟计划为蓝本的计划。 2014年，我们进行了可行性研究 槟榔戒除计划。该计划受到热烈欢迎，并产生了令人惊讶的高自学率。 据报道已停止槟榔。 我们的主要目的是测试基于小组的强化槟榔戒除计划的功效。槟榔 戒烟将通过使用我们之前研究中开发的生物标志物进行生物验证。参加者 (n=324) 是关岛和塞班岛的槟榔咀嚼者，他们愿意尝试戒掉咀嚼。 参与者将被随机分配到强化干预条件或最小干预条件 控制条件。处于干预条件的参与者将接受基于团体的戒烟计划 包括为期 22 天、时长 5 小时的课程，以及包含戒烟建议的小册子 槟榔。控制条件下的参与者将收到一本小册子，其中包含有关戒除槟榔的建议。这 拟议的干预试验将使我们能够评估干预措施的 1 个月和 6 个月疗效 与最低限度的控制干预相比。我们假设强化槟榔戒断干预 与 6 个月的最低控制条件相比，将产生显着更高的戒烟率 后续评估。