Analytic Core

分析核心

• 批准号: 9207387
• 负责人: Warren Scott Comulada
• 金额: $ 55.75万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9207387
• 关键词: AIDS prevention; Accounting; Address; Adolescent; Algorithms; Behavior; Behavioral Research; Biological; Biological Markers; Bisexual; Car Phone; Caring; Clinic; Communities; Comorbidity; Complex; Computer software; Consult; Consultations; Cost Effectiveness Analysis; Data; Data Analyses; Data Collection; Data Quality; Data Security; Data Storage and Retrieval; Development; Drug usage; Electronics; Enrollment; Ensure; Evaluation Studies; Gays; HIV; HIV Infections; HIV risk; Health Insurance Portability and Accountability Act; Homeless Youth; Homelessness; Hot Spot; Information Dissemination; Intervention; Lead; Leadership; Maps; Mental Health; Methods; Modeling; Online Systems; Outcome; Outcome Assessment; Outcome Measure; Paper; Participant; Patient Self-Report; Prevention; Prevention strategy; Protocols documentation; Publications; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Research Design; Research Personnel; Research Priority; Research Support; Risk; Risk Factors; Sampling; Scientist; Services; Site; Social Work; Spottings; Statistical Methods; Technology; Time; United States National Institutes of Health; Ursidae Family; Work; Writing; Youth; abstracting; base; behavioral outcome; care delivery; cloud based; cost; cost effectiveness; data management; experience; high risk; implementation science; innovation; interest; multilevel analysis; social media; social networking website; standard of care; tool; transgender; transmission process; treatment strategy; web portal

Project Summary/Abstract Adolescent HIV interventions call for more advanced analytic approaches than traditional HIV studies have used. HIV prevention and treatment research trials have traditionally been conducted in a randomized controlled trial (RCT) framework where study participants, often recruited from social service agencies, are randomized into an intervention or standard of care condition and followed over time. Outcome measures consist of self-reported mental health and HIV transmission behaviors. Three large changes are necessary for adolescent studies in the modern era of HIV research. First, youth are often difficult to identify and engage in HIV care. Innovative recruitment strategies that make use of traditional and technology-based methods are necessary to maximize efforts. Second, NIH research priorities target biomedical HIV endpoints. Combination strategies that target HIV end points and comorbid conditions are needed. Lastly, researchers need to plan for intervention delivery in real-world settings. Youth deal with many complex issues, such as homelessness, that can impede access to and delivery of care, directly impacting biological outcome markers. Studies in the proposed U19 proposal will address current challenges in HIV research by using comprehensive youth engagement strategies and combination prevention strategies to address HIV end points and comorbidities. Statistical methods will be used to evaluate interventions in the RCT framework through complex multilevel models (MLM) to evaluate multiple end points over time. In addition, implementation science methods will be used to examine barriers to HIV care and engagement in clinic settings. The Analytic Core provides a range of technological, biomedical, and behavioral research expertise that will support research in the current U19 proposal. The Analytic Core is comprised of statisticians with expertise in fitting complex MLM in HIV studies that contain both biomarker and behavioral outcomes. Technologists are also a part of the Core and have used social media recruitment tools, mobile phone-based assessment, and cloud-based data storage in their own HIV research. The Analytic Core also fields expertise in implementation science and cost effectiveness analysis that will be used to address study aims. The Analytic Core will support research across U19 projects through the following specific aims. First, we will provide consultation on web- based tools that will enhance standard recruitment methods and finalize the recruitment sample of seronegative youth based on risk factors from a larger pool of seronegative youth. Second, data collection will be centralized to maximize data quality and security, minimize costs, and facilitate analysis. Dimagi CommCare software that we have used in prior HIV research will be used and provides an integrated package to provide HIPAA-compliant cloud-based data storage and mobile phone or web-based data entry. Third, Core scientists will conduct innovative analyses that include biological, engagement, and behavioral outcomes. Lastly, the Analytic Core will coordinate with the Management Core for timely dissemination of study findings.

项目概要/摘要 青少年艾滋病毒干预措施需要比传统艾滋病毒研究更先进的分析方法 用过的。艾滋病毒预防和治疗研究试验传统上是随机进行的 对照试验（RCT）框架，其中研究参与者通常是从社会服务机构招募的 随机分为干预措施或标准护理条件，并随时间推移进行随访。结果衡量 包括自我报告的心理健康和艾滋病毒传播行为。需要进行三大变革 现代艾滋病毒研究中的青少年研究。首先，青少年往往难以识别和参与 艾滋病毒护理。利用传统和基于技术的方法的创新招聘策略 需要最大限度地努力。其次，美国国立卫生研究院的研究重点是针对艾滋病毒生物医学终点。组合 需要针对艾滋病毒终点和合并症的策略。最后，研究人员需要制定计划 在现实环境中进行干预。青年人要处理许多复杂的问题，例如无家可归， 可能会阻碍获得和提供护理，直接影响生物结果标记。研究领域 拟议的 U19 提案将通过利用全面的青年来解决当前艾滋病毒研究的挑战 解决艾滋病毒终点和合并症的参与策略和综合预防策略。 将使用统计方法通过复杂的多层次评估 RCT 框架中的干预措施 模型（MLM）随着时间的推移评估多个终点。此外，实施科学方法将 用于检查艾滋病毒护理和参与诊所环境的障碍。 分析核心提供一系列技术、生物医学和行为研究专业知识，将 支持当前 U19 提案中的研究。分析核心由具有以下专业知识的统计学家组成 将复杂的传销纳入包含生物标志物和行为结果的艾滋病毒研究中。技术人员是 也是核心的一部分，并使用了社交媒体招聘工具、基于手机的评估，以及 他们自己的艾滋病毒研究中基于云的数据存储。分析核心还拥有实施方面的专业知识 将用于实现研究目标的科学和成本效益分析。分析核心将支持 通过以下具体目标对 U19 项目进行研究。首先，我们将通过网络提供咨询- 的工具，将加强标准招聘方法并最终确定招聘样本 血清阴性青少年基于来自更多血清阴性青少年的危险因素。其次，数据收集将 集中化以最大限度地提高数据质量和安全性、最大限度地降低成本并促进分析。迪马吉 我们将使用我们在之前的 HIV 研究中使用的 CommCare 软件，并提供一个集成包 提供符合 HIPAA 的基于云的数据存储和移动电话或基于 Web 的数据输入。三、核心 科学家将进行创新分析，包括生物学、参与度和行为结果。 最后，分析核心将与管理核心协调，及时传播研究结果。